Enlarge / A vial containing Moderna COVID-19 booster vaccine at a vaccination center. (credit: Getty | SOPA Images )

A vaccine advisory group for the World Health Organization said Tuesday that, at this point, it does not recommend additional, let alone annual COVID-19 booster shots for people at low to medium risk of severe disease. It advised countries to focus on boosting those at high risk—including older people, pregnant people, and those with underlying medical conditions—every six to 12 months for the near- to mid-term.

The new advice contrasts with proposed plans by US Food and Drug Administration , which has suggested treating COVID-19 boosters like annual flu shots for the foreseeable future. That is, agency officials have floated the idea of offering updated formulations each fall, possibly to everyone, including the young and healthy.

In a viewpoint published last May in JAMA , the FDA's top vaccine regulator, Peter Marks, along with FDA Commissioner Robert Califf and Principal Deputy Commissioner Janet Woodcock, argued that annual COVID booster campaigns in the fall, ahead of winter waves of respiratory infections—such as flu, COVID-19, and RSV—would protect health care systems from becoming overwhelmed. And they specifically addressed the possibility of vaccinating those at low risk.

Enlarge / A person wearing a tinfoil hat on September 20, 2019. (credit: Getty | Bridget Bennett )

In the latest efforts by Republican lawmakers to enshrine into law Americans' right to freely spread deadly infectious diseases to each other, the Missouri House this week advanced a bill that would bar governments, schools, and employers from mandating certain vaccines—as well as things like vaccine microchips, which do not exist.

The bill, HB 700 ( PDF ), was sponsored by Rep. Bill Hardwick, a Republican from Waynesville. Hardwick told the St. Louis Post-Dispatch that he believed people " lost their minds " during the COVID-19 pandemic, and that legally barring officials and employers from requiring life-saving vaccination, even among health care workers, feels "like it's the right thing to do."

The bill specifically bars requirements for people to receive COVID-19 vaccines. But it doesn't stop there. It also bars any requirements for people to receive "a dose of messenger ribonucleic acid (mRNA)," thus barring requirements for any future mRNA-based vaccines, should they be needed in upcoming pandemics or outbreaks. It also bars requirements for "any treatment or procedure intended or designed to edit or alter human deoxyribonucleic acid (DNA) or the human genome," and "any mechanical or electronic device" that would be placed "under the skin."

Enlarge / Moderna CEO Stephane Bancel testifies before the Senate Health, Education, Labor, and Pensions Committee in the Hart Senate Office Building on Capitol Hill on March 22 in Washington, DC. (credit: Getty | Chip Somodevilla)

In Congressional testimony Wednesday, Moderna CEO Stéphane Bancel unabashedly defended the company's plans to raise the US list price of its COVID-19 vaccines by more than 400 percent—despite creating the vaccine in partnership with the National Institutes of Health, receiving $1.7 billion in federal grant money for clinical development, and making roughly $36 billion from worldwide sales.

Bancel appeared this morning before the Senate's Health, Education, Labor, and Pensions committee, chaired by Sen. Bernie Sanders (I-Vt.), who has long railed at the pharmaceutical price gouging in the US and pushed from policy reforms. After thanking Bancel for agreeing to testify, Sanders didn't pull any punches. He accused Moderna of "profiteering" and sharing in the "unprecedented level of corporate greed" seen in the pharmaceutical industry generally.

Sanders contrasted a recent survey finding that 37 percent of Americans can't afford their prescription drugs to the billions of dollars in profits reaped by drug companies. He noted several times that Bancel became a billionaire overnight amid the pandemic. Bancel is now estimated to be worth over $4 billion, Sanders added.

Enlarge / Security guards stand in front of the closed Huanan Seafood Wholesale Market in the city of Wuhan, in the Hubei Province, on January 11, 2020, where the Wuhan health commission said that the man who died from a respiratory illness had purchased goods. (credit: Getty | NOEL CELIS )

A group of independent, international researchers has released its full analysis of newly uncovered metagenomic data collected by the Chinese Centers for Disease Control and Prevention in January and February of 2020. The data closely links SARS-CoV-2 to the genetic tracks of wild animals, particularly raccoon dogs , sold at the Huanan Wholesale Seafood Market in Wuhan, China, the early epicenter of the COVID-19 pandemic, the group's analysis says.

The full analysis provides additional, compelling evidence that the pandemic coronavirus made its leap to humans through a natural spillover, with a wild animal at the market acting as an intermediate host between the virus' natural reservoir in horseshoe bats and humans. It was authored by 19 scientists, led by Michael Worobey, an evolutionary biologist at the University of Arizona; Kristian Andersen, a virologist at the Scripps Research Institute in California; and Florence Débarre, a theoretician who specializes in evolutionary biology at France's national research agency, CNRS.

Prior to the release of the full analysis late Monday, information on the findings was only made public through media reports and statements from the World Health Organization, which was briefed on the analysis last week. But, the raw metagenomic data behind the analysis is still not publicly available. It was briefly posted on a public genetic database called the Global Initiative on Sharing Avian Influenza Data (GISAID) as recently as earlier this month, and the international researchers were able to download it during that window of availability. But, administrators for the database quickly removed the data after its discovery, saying the removal was at the request of the submitter, a researcher at China CDC.

Enlarge / The director of Germany's National Reference Centre for Invasive Fungal Infections holds a petri dish containing the yeast Candida auris in a laboratory at Wuerzburg University. (credit: Getty | Nicolas Armer )

A deadly, drug-resistant fungus emerging in the US gained ground faster and picked up yet more drug resistance amid the COVID-19 pandemic, researchers at the Centers for Disease Control and Prevention reported Monday.

The yeast Candida auris has been considered an "urgent threat"—the CDC's highest level of concern—since it was first reported in the US in 2016. The yeast lurks in health care settings and preys upon vulnerable patients, causing invasive infections with a fatality rate of between 30 to 60 percent.

In 2019, before the pandemic began, 17 states and Washington, DC, reported a total of 476 clinical cases. But in 2020, eight additional states reported cases for the first time, with the national clinical case count jumping 59 percent to 756. In 2021, 28 states were affected, with the clinical case count nearly doubling to 1,471. Asymptomatic cases detected through patient screening also jumped amid the pandemic, tripling from 1,310 cases in 2020 to 4,041 cases in 2021. The data appeared Monday in the Annals of Internal Medicine.

Enlarge / A raccoon dog at the Chapultpec Zoo in Mexico City on August 6, 2015. (credit: Getty | ALFREDO ESTRELLA/ )

Newly obtained genetic data from the Chinese Center for Disease Control and Prevention (China CDC) links the pandemic coronavirus SARS-CoV-2 to animals—specifically raccoon dogs—at the Huanan Seafood Wholesale Market in Wuhan, where the earliest COVID-19 cases centered, a group of independent scientists told the World Health Organization this week.

The genetic data came from environmental swabs collected at the market by China CDC in January of 2020. The existence of these swabs was previously known, as was the fact that they were positive for SARS-CoV-2 genetic material. But in late January of this year, scientists at China CDC uploaded—and then later removed—additional genetic data from these swabs to a public genetic database called GISAID, the WHO said. That additional data, which had not been previously disclosed, indicates that the SARS-CoV-2-positive swabs also contained genetic material from humans and animals, particularly large amounts of genetic material that closely matches that of raccoon dogs.

Raccoon dogs—foxlike animals whose faces closely resemble those of raccoons—are known to be susceptible to SARS-CoV-2 infection and were known to be sold at the market.

Enlarge / Florida Surgeon General Joseph Ladapo speaks at a press conference in Rockledge, Florida, on August 3, 2022. (credit: Getty | SOPA Images )

At the height of the pandemic, Florida Governor Ron DeSantis repeatedly promoted COVID-19 vaccines , saying correctly that "they're safe, they're effective," and they "are saving lives." With hundreds of millions of shots given worldwide at this point, the extensive international data on the vaccines' safety and efficacy have strongly and consistently backed DeSantis' statements. The vaccines are estimated to have saved over 14 million lives in 185 countries just in the pandemic's first two years .

But amid growing rumors of a 2024 presidential bid, DeSantis reversed his stance on the life-saving shots, abruptly questioning their efficacy and making unfounded claims about their safety. In December, his about-face culminated in a call for a grand jury to investigate any alleged " crimes and wrongdoing " related to the vaccines.

Though the swing appears more aimed at scoring political points than protecting Floridians' health, DeSantis' hand-picked surgeon general, Joseph Ladapo, has hewed closely to the governor's anti-vaccine rhetoric and health misinformation. Since his appointment as Florida's top doctor in late 2021, Ladapo has made false claims about vaccines, encouraged vaccine hesitancy, opposed masks, downplayed the health effects of COVID-19, and promoted ineffective COVID-19 treatments, such as ivermectin .

Enlarge / A microscope image of Streptococcus pyogenes , a common type of group A strep. (credit: Getty | BSIP )

In the wake of the COVID-19 pandemic and amid a tall wave of respiratory viruses, health officials in Colorado and Minnesota documented an unusual spike in deadly, invasive infections from Streptococcus bacteria late last year, according to a study published this week by the Centers for Disease Control and Prevention .

The spike is yet another oddity of post-pandemic disease transmission, but one that points to a simple prevention strategy: flu shots.

The infections are invasive group A strep , or iGAS for short, which is caused by the same group of bacteria that cause relatively minor diseases, such as strep throat and scarlet fever. But iGAS occurs when the bacteria spread in the body and cause severe infection, such as necrotizing fasciitis (flesh-eating disease), toxic shock syndrome, or sepsis. These conditions can occur quickly and be deadly.