Enlarge / Transmission electron micrograph of a SARS-CoV-2 virus particle isolated from a patient sample and cultivated in cell culture. (credit: Getty | BSIP )

A remarkably mutated coronavirus variant classified as BA.2.86 seized scientists' attention last week as it popped up in four countries, including the US.

So far, the overall risk posed by the new subvariant is unclear. It's possible it could lead to a new wave of infection; it's also possible (perhaps most likely) it could fizzle out completely. Scientists simply don't have enough information to know. But, what is very clear is that the current precipitous decline in coronavirus variant monitoring is extremely risky.

In a single week, BA.2.86 was detected in four different countries, but there are only six genetic sequences of the variant overall —three from Denmark, and one each from Israel, the UK, and the US (Michigan). The six detections suggest established international distribution and swift spread. It's likely that more cases will be identified. But, with such scant data, little else can be said of the variant's transmission or possible distribution.

Enlarge / A picture of containers taken from the illegal UMI lab in Reedley, California. (credit: FCDPH )

The Food and Drug Administration is warning consumers not to use any at-home tests made by Universal Meditech, Inc. (UMI), the company behind an illegal medical lab hidden in a warehouse in the small city of Reedley, California. The lab was shut down earlier this year by local, state, and federal agencies, which are still working to clear the site, properly dispose of all its hazardous contents, and investigate those responsible.

"UMI has notified the FDA that it has stopped all operations and is no longer providing support for its tests," the FDA said in a safety communication Friday . "The FDA is not able to confirm the performance of UMI’s tests, raising concerns that the tests may not be safe and effective."

UMI manufactured a variety of strip-based tests, mostly pregnancy tests, but also tests for ovulation, ketones, and alcohol in breast milk. The tests were sold under several names—including DiagnosUS, HealthyWiser, DeTec, and PrestiBio. They were available online from at least four distributors, which may not have identified UMI as the manufacturer. The known distributors are: AC&C Distribution, LLC; HealthyWiser; Home Health US Inc.; and Prestige Biotech Inc. The FDA cautions that there may be other distributors that it doesn't know about.

Enlarge (credit: Getty | Bill Diodato )

The top 25 costliest drugs for Medicare Part D plans earned their lofty rankings largely through exorbitant price hikes—increases that, on average, more than tripled their list prices since they entered the market, according to a new analysis by AARP .

For nearly all the drugs, the price hikes far outstripped the rate of inflation, with increases ranging from 20 percent to 739 percent during the drugs' lifetimes on the market. Only one of the top 25 drugs—Trelegy Ellipta, an inhaler for asthma and chronic lung conditions—had price increases that were below the rate of inflation during its time on the market. Since its initial release in 2017, Trelegy Ellipta's price increased only 20 percent, compared with a general inflation rate of 23 percent.

Overall, the average lifetime price increase for the top 25 drugs was 226 percent. The highest increases were seen in drugs that have been on the market the longest. For example, drugs that were on the market for under 12 years had an average lifetime price increase of 58 percent, while those on the market for 20 or more years had an average lifetime increase of 592 percent.

Enlarge / Researchers use CyBio FeliX workstations to extract and purify DNA samples for testing (credit: LabGenius)

At an old biscuit factory in South London, giant mixers and industrial ovens have been replaced by robotic arms, incubators, and DNA sequencing machines. James Field and his company LabGenius aren’t making sweet treats; they’re cooking up a revolutionary, AI-powered approach to engineering new medical antibodies.

In nature, antibodies are the body’s response to disease and serve as the immune system’s front-line troops. They’re strands of protein that are specially shaped to stick to foreign invaders so that they can be flushed from the system. Since the 1980s, pharmaceutical companies have been making synthetic antibodies to treat diseases like cancer, and to reduce the chance of transplanted organs being rejected.

Enlarge / An armadillo prepares to cross a gravel road as the space shuttle Endeavour rests on the launch pad at Kennedy Space Center before the scheduled launch of STS-130 in Cape Canaveral, Florida, February 4, 2010. (credit: Getty | JIM WATSON )

A Florida man's unexplained case of leprosy last year adds to mounting evidence that the rare and often misunderstood bacterial infection has become endemic to the central part of the Sunshine State—and that it may, in fact, lurk in the environment there, possibly in the soil.

In a research letter appearing in the August issue of Emerging Infectious Diseases, three dermatologists detailed the man's case and their concerns for local transmission. They note that the 54-year-old man, like several others in the state who contracted the disease, reported no established risk factors that might explain their infection. He hadn't traveled abroad, where he could have picked up the infection, or had any exposure to armadillos, which live in Florida and naturally carry the bacteria that cause leprosy. He also didn't have any prolonged contact with people from leprosy-endemic countries or connections to anyone known to have leprosy.

But he did spend a lot of time outdoors; he worked as a landscaper. In fact, many of the recent Florida cases lacked traditional risk factors but reported spending a lot of time outdoors. The similarity "supports the investigation into environmental reservoirs as a potential source of transmission," the doctors wrote.

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Internal dissent within the mostly volunteer disease-news network known as ProMED—which alerted the world to the earliest cases of COVID , Middle East Respiratory Syndrome (MERS), and SARS—has broken out into the open and threatens to take down the internationally treasured network unless an external sponsor can be found.

The struggle for the future of the low-tech site, which also sends out each piece of content on a no-reply email list with 20,000 subscribers, has been captured in dueling posts to its front page. On July 14, a post by ProMED’s chief content officer, a veterinarian and infectious-disease expert named Jarod Hanson , announced that ProMED is running out of money. Because it is being undermined by data-scraping and reselling of its content, Hanson wrote, ProMED would turn off its RSS and Twitter feeds, limit access to its decades of archives to the previous 30 days, and introduce paid subscriptions.

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For a fourth consecutive summer, COVID-19 is on the rise, though this year's warm-weather wave appears milder than those in the emergency period of the pandemic.

COVID-19 indicators of hospital admissions, emergency department visits, test positivity, and wastewater levels have all been increasing in the past month, with a peak not yet clearly in sight, according to data tracking by the Centers for Disease Control and Prevention. From June 10 to July 29, test positivity rose from 4.1 percent to 8.9 percent. For reference, the most recent winter wave had a peak test positivity of 10.6 percent on December 31, 2022.

On the brighter side, however, weekly COVID-19 hospital admissions and deaths continue to be at their lowest points since the start of the pandemic. For now, deaths do not appear to be rising, though there are lags in data reporting. Weekly new hospital admissions are ticking up only slightly—with admissions rising to about 8,000 in the week of July 22, up from around 6,300 the week of June 24.

Enlarge (credit: Getty | Portland Press Herald )

Local and federal authorities have shut down what seems to be an illegal medical lab hidden in a California warehouse that contained nearly 1,000 laboratory mice, hundreds of unknown chemicals, refrigerators and freezers, vials of biohazardous materials, including blood, incubators, and at least 20 infectious agents, including SARS-CoV-2, HIV, and a herpes virus.

According to NBC News affiliate KSEE of Fresno , local authorities were first tipped off to the unlicensed facility when a local code enforcement officer noticed that a garden hose was illegally attached to the back of the building. That led city officials to obtain a search warrant to inspect the warehouse, which was supposed to only be used for storage.

According to court documents obtained by NBC News , city officials inspected the warehouse, located in Reedley, southeast of Fresno, on March 3. County health officials then inspected the facility on March 16. What they found reportedly shocked them.